Chronic Inflammation is known as “regulation rigidity”?

Immunomodulation as a means to overcome "regulation rigidity".

An appropiate immune response is stimulated by cytokines released by T-helper cells according to the antigen that is encountered. TH1 cells generally react to virus and fungal infections and directly attack the antigen. TH2 cells stimulate the formation of antibodies but also release pro-inflammatory cytokines that are closely involved in the allergic response.

Healthy individuals usually have a small daily oscillation between TH1 and TH2 cells so that the body is primed to respond in a certain fashion. People with allergies are more disposed to the TH2 response. This means that the immune system will more easily access the TH2 pathway in response to antigens and cause allergic reactions more easily.

In Homotoxicology this is called "regulation rigidity". The induction of a TH3 response can overcome this situation and restore normal physiological balance between TH1 and TH2 cells. Traumeel has been shown to down-regulate the proinflammatory cytokines and increase TGF-B, an anti-inflammatory cytokine. This is called the "Bystander reaction".